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Презентация на тему SIW Crohn’s disease

Crohn's disease - is a multisystem disease with a specific clinical picture, characterized by focal, asymmetric, transmural granulomatous inflammation, which affects primarily the gastrointestinal tract; but can also be manifested by systemic and extraintestinal complications.
SIW Crohn’s diseaseSmagulova Aida, 463 GMJSC Astana Medical UniversityDepartment of Internal Diseases Crohn's disease - is a multisystem disease with a specific clinical picture, Etiology EtiologyAccording to the Crohn’s and Colitis Foundation of America, between 5 and Pathogenesis The terminal segment of the ileum is most often affected (85-90%) Clinical manifestations. intestinal manifestationsAcuteChronic1)growing pains in the right lower quadrant2)vomiting3)diarrhea with an combined defeat of the small intestine and colonlocalization in the upper gastrointestinal extraintestinal DiagnosticsComplaints of patientAnamnesisPhysical examinationLaboratory and instrumental research Laboratory research GBA; GUA;A biochemical blood test; Coprogramme; admixture of blood and Changes Endoscopic examination of the upper sections of the gastrointestinal tract and lower a - single aphthous lesions of the rectum b - multiple aphthous endoscopic scale of Crohn's disease microscopic examinationgranuloma with Langhans cellsNB! One of the significant microscopic differences of a) aphthous ulcersb) “cobblestone pavement”c) crawling ulcersd) stricture of terminal ileum DIFFERENTIAL DIAGNOSTICS perforationtoxic colon dilatationintestinal bleedingfistulasstrictureComplications Complications Treatment Treatment Secondary prevention of Crohn's disease  Measures of primary prevention of IBD BibliographyПротокол № 23 от «25» мая 2017  года. Болезнь крона [регионарный энтерит]
Слайды презентации

Слайд 2
Crohn's disease - is a multisystem disease with

Crohn's disease - is a multisystem disease with a specific clinical

a specific clinical picture, characterized by focal, asymmetric, transmural

granulomatous inflammation, which affects primarily the gastrointestinal tract; but can also be manifested by systemic and extraintestinal complications.

Слайд 4 Etiology

Etiology

Слайд 5 Etiology
According to the Crohn’s and Colitis Foundation of

EtiologyAccording to the Crohn’s and Colitis Foundation of America, between 5

America, between 5 and 20 percent of people who


have an IBD have a first – degree relative with one. the risk is higher in Crohn’s than ulcerative colitis,
and higher when both parents are affected.



Слайд 6 Pathogenesis

Pathogenesis

Слайд 7 The terminal segment of the ileum is most

The terminal segment of the ileum is most often affected (85-90%)

often affected (85-90%)


Слайд 9 Clinical manifestations. intestinal manifestations
Acute
Chronic


1)growing pains in the right lower

Clinical manifestations. intestinal manifestationsAcuteChronic1)growing pains in the right lower quadrant2)vomiting3)diarrhea with

quadrant
2)vomiting
3)diarrhea with an admixture of blood
4)flatulency
5)fever
6)thickened painful terminal segment

of the ileum
7)leukocytosis


Localization in

small intestine

colon


a)General symptoms:
1)Malabsorption
syndrome

2)Intoxication syndrome
b)Local symptoms


1)stomach ache
2)diarrhea
3)pallor, dry skin
4)decreased muscle tone of the anterior abdominal wall
5)palpation of the colon is painful


Слайд 10 combined defeat of the small intestine and colon
localization

combined defeat of the small intestine and colonlocalization in the upper

in the upper gastrointestinal tract
symptoms of terminal ileitis and


colon damage

ulcerative syndrome

clinic of chronic gastritis and esophagitis


Слайд 11 extraintestinal

extraintestinal

Слайд 12 Diagnostics
Complaints of patient
Anamnesis
Physical examination
Laboratory and instrumental research

DiagnosticsComplaints of patientAnamnesisPhysical examinationLaboratory and instrumental research

Слайд 13 Laboratory research
GBA;
GUA;
A biochemical blood test;

Laboratory research GBA; GUA;A biochemical blood test; Coprogramme; admixture of blood


Coprogramme; admixture of blood and mucus
Definition of HIV (differential

diagnosis of diarrheal syndrome)
Immunological status;
Fecal calprotectin can be recommended


Слайд 14 Changes

Changes

Слайд 15 Endoscopic examination of the upper sections of the

Endoscopic examination of the upper sections of the gastrointestinal tract and

gastrointestinal tract and lower parts (ileocolonoscopy) is carried out

to confirm the diagnosis of IBD, to obtain tissue samples for morphological analysis for the purpose of differential diagnosis between UC and CD.
The presence of transverse ulcers, aphthae, limited areas of hyperemia and edema in the form of a "geographical map", fistulas with localization in any part of the gastrointestinal tract is characteristic of CD.
Ileocolonoscopy is the first line diagnostic method for the detection of terminal ileitis

Слайд 16
a - single aphthous lesions of the rectum

a - single aphthous lesions of the rectum b - multiple

b - multiple aphthous ulcers found in colonoscopy c

- characteristic linear ulcers r - "cobblestone pavement" with a relatively small surface of ulceration

Слайд 17 endoscopic scale of Crohn's disease

endoscopic scale of Crohn's disease

Слайд 18 microscopic examination
granuloma with Langhans cells
NB! One of the

microscopic examinationgranuloma with Langhans cellsNB! One of the significant microscopic differences

significant microscopic differences of Crohn's disease from ulcerative colitis

is the spread of inflammatory infiltrate to all layers of the intestinal wall (transmural nature of inflammation)

Слайд 19
a) aphthous ulcers
b) “cobblestone pavement”
c) crawling ulcers
d) stricture

a) aphthous ulcersb) “cobblestone pavement”c) crawling ulcersd) stricture of terminal ileum

of terminal ileum


Слайд 20 DIFFERENTIAL DIAGNOSTICS

DIFFERENTIAL DIAGNOSTICS

Слайд 23 perforation
toxic colon dilatation
intestinal bleeding
fistulas
stricture
Complications

perforationtoxic colon dilatationintestinal bleedingfistulasstrictureComplications

Слайд 24 Complications

Complications

Слайд 25 Treatment

Treatment

Слайд 27 Treatment

Treatment

Слайд 28 Secondary prevention of Crohn's disease
Measures of primary

Secondary prevention of Crohn's disease Measures of primary prevention of IBD

prevention of IBD have not been developed.
The patient should

follow the diet throughout life. Also, such patients are advised to stop smoking and treat infectious diseases of the intestine.
With the preventive purpose, the same medicines are used, which are used to treat exacerbations of the disease, but in smaller doses (mesalazine at 2 grams per day, etc.).
 Regular consultations of the gastroenterologist. Should be visited every 3 to 6 months.
Timely treatment of relapse of the disease.

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