Презентация на тему Тератогенез. Факторы внешней среды. Вирусы. Воспаление. Эндокринные нарушения. Генетические нарушения. (Часть 8)

морфогенез мышей

и апоптоза

certain natural foods (fruits, leafy green vegetables,
beans and liver)

as polyglutamate. The synthetic form, folic acid (a
monoglutamic acid), is used in food fortification and vitamin preparations.
Folic acid has a higher bioavailability than food folate

в развитии нервной системы
и др. нарушения

балансе
- множественные нарушения

восстановительного цикла, используются, в том числе, для лечения эпилепсии,

аритмии и рака, проходит реакцию одно-электронного восстановления с выходом свободных радикалов.

в uterine-placental unit, the placental-fetal unit

receptors (миграция нейронов)
5-Hydroxytryptamine receptors
and transporters (Serotonin (5-hydroxytryptamine, 5-HT) is

a monoamine neurotransmitter)

that catalyze the reversible hydration of CO2 into the

bicarbonate ion and protons. This reaction
is involved in many biological processes, including pH homeostasis,
respiration, biosynthetic reactions and bone resorption.
2. g-Aminobutyric acid receptors
In vertebrates, g-aminobutyric acid (GABA) is the major inhibitory
neurotransmitter, which binds to specific transmembrane GABA
receptors. Extraneuronal GABA-ergic systems are thought to be
present in other tissues as well, including the testis

doi: 10.1016/j.reprotox.2012.10.007. Epub 2012 Oct 23.
Teratogenic effects of diabetic

conditions in chick heart in ovo and in micromass culture may be prevented by addition of vitamin C and folic acid.
Memon SMemon S, Pratten MK.
Source
Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Abstract
Maternal diseases like diabetes mellitus may cause developmental defects. Supplementation with folic acid and vitamin C during the periconceptional period has been shown to prevent some neural tube and congenital heart defects. Hearts were dissected from 5 days-old White Leghorn chick embryos, the cells isolated and cultured in micromass under diabetic conditions, with and without folic acid and vitamin C. Contractile activity, cell viability (resazurin reduction) and protein assays were performed. Results indicated diabetic conditions reduced contractile activity and cell viability, whilst vitamin C (100 μM) and folic acid (1 mM) administered concurrently significantly improved them to values comparable with the control. Day 3 chick embryos in ovo were injected with glucose+hydroxybutyrate or a combination of these and vitamins. Diabetic conditions caused gross and histological malformations, but these effects were abrogated by vitamin supplement. Teratogenic effects on heart development could possibly be prevented by vitamin supplementation during pregnancy.