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Презентация на тему АНТИДЕПРЕСАНТЫ

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Overview 10700 y.a. – The betel nut was chewed in Thailand  7000 y.a. – Coca was being used in the Andes  Before European contact – Native Americans used tobacco
Psychoactive substances and drugs. AntidepressantsZvereva Milaschool of pharmacy Overview 10700 y.a. – The betel nut was chewed in Thailand  7000 y.a. LegalityThe resolution of the government of Russian Federation N 681 (30.06.1998) 1) list Mechanisms and effectsAgonists:increasing the synthesis of one or more neurotransmittersreducing its reuptake from the synapses mimicking the Mechanisms and effects thujone, bicuculline Addictionpsychological dependence physical dependence UsageAnxiolyticsExample: Benzodiazepine	EuphoriantsExample: MDMA (Ecstasy), MDA, 6-APB, IndopanStimulants ( Ritual and spiritual Recreation alcohol –in most areas of the world it is legal for those PharmacoyherapyAnesthesiaPain managementMental disorders Depression and Antidepressants Key facts:Depression is a common mental disorder. Globally, more Drugs used for the treatment of depression: Selective serotonin reuptake inhibitors (SSRIs)Serotonin/norepinephrine Selective serotonin reuptake inhibitors, SSRIs Citalopram (Celexa) Escitalopram (Lexapro) Fluoxetine (Prozac) Paroxetine (Paxil) Sertraline (Zoloft) Vilazodone (Viibryd)Vortioxetine (Brintellix) Serotonin/norepinephrine reuptake inhibitors, SNRIs Desvenlafaxine (Pristiq) Duloxetine (Cymbalta)Venlafaxine (Effexor, Effexor XR)Levomilnacipran (Fetzima) Other Antidepressants  Bupropion (Wellbutrin)Mirtazapine (Remeron, Remeron SolTab)Trazodone (Desyrel, Oleptro) Tricyclic antidepressants, TCAs Amitriptyline (Elavil) Desipramine (Norpramin) Imipramine (Tofranil) Clomipramine (Anafranil) Nortriptyline (Pamelor) Protriptyline (Vivactil)Doxepin (Sinequan, Silenor)Trimipramine (Surmontil) Amoxapine  Monoamine oxidase inhibitors,MAO IsSelegiline transdermal patch (Emsam)Tranylcypromine (Parnate) Phenelzine (Nardil) Isocarboxazid (Marplan) HerbalsHypericum perforatum (St John's Wort) The End
Слайды презентации

Слайд 2 Overview
 10700 y.a. – The betel nut was chewed

Overview 10700 y.a. – The betel nut was chewed in Thailand  7000

in Thailand
 7000 y.a. – Coca was being used

in the Andes
  Before European contact – Native Americans used tobacco

Слайд 3 Legality
The resolution of the government of Russian Federation

LegalityThe resolution of the government of Russian Federation N 681 (30.06.1998) 1)

N 681 (30.06.1998)
1) list I: mescaline and its derivatives,

hashish, heroin, marijuana, methadone, MMDA, opium, psilocybin , psilocin, ephedrine, etc.
2) list II: codeine, cocaine, morphine, ethylmorphine, omnopon, fentanyl, promedol, etc.
3) list III: barbital, nitrazepam, diazepam, taren, etc.
4) list IV:ephedrine, pseudoephedrine, acetone, sulphuric acid, hydrochloric acid, potassium permanganate, acetic acid, etc.

Слайд 4 Mechanisms and effects
Agonists:
increasing the synthesis of one or more neurotransmitters
reducing

Mechanisms and effectsAgonists:increasing the synthesis of one or more neurotransmittersreducing its reuptake from the synapses mimicking

its reuptake from the synapses
mimicking the action by binding directly to

the postsynaptic receptor
Antagonists:
interfering with synthesis
blocking postsynaptic receptors

Слайд 5 Mechanisms and effects

Mechanisms and effects

Слайд 6 thujone, bicuculline


thujone, bicuculline

Слайд 7 Addiction
psychological dependence
 physical dependence

Addictionpsychological dependence physical dependence

Слайд 8 Usage
Anxiolytics
Example: Benzodiazepine
Euphoriants
Example: MDMA (Ecstasy), MDA, 6-APB, Indopan
Stimulants ("uppers")
Examples: amphetamine, caffeine, cocaine, nicotine
Depressants ("downers"), including sedatives, hypnotics, and narcotics.
Examples: ethanol (alcoholic beverages), opioids,  barbiturates, 

UsageAnxiolyticsExample: Benzodiazepine	EuphoriantsExample: MDMA (Ecstasy), MDA, 6-APB, IndopanStimulants (

benzodiazepines
Hallucinogens, including  psychedelics, dissociatives and deliriants
Examples: psilocybin, LSD, Salvia divinorum and nitrous oxide


Слайд 9 Ritual and spiritual

Ritual and spiritual

Слайд 10 Recreation
alcohol –in most areas of the world it is

Recreation alcohol –in most areas of the world it is legal for

legal for those over a certain age
tobacco – a legal

drug
cannabis
caffeine - a legal drug, contained in coffee, tea, energy drinsks, and some soft drinks
MDMA
cocaine 
amphetamines – prescribed for ADHD
psilocybin mushrooms 
LSD –banned in October 1968 by US President Lyndon B Johnson.
opiates and opioids – available by prescription.
tranquilizers – barbiturates, benzodiazepines - commonly prescribed for anxiety
nitrous oxide - legal
ketamine – used by paramedics in emergency situations for its  dissociative  and  analgesic qualities
amyl nitrite – a vasodilator (legal)
other drugs (antidepressants, tranquilizers, analgesics, etc)

Слайд 11 Pharmacoyherapy
Anesthesia
Pain management
Mental disorders

PharmacoyherapyAnesthesiaPain managementMental disorders

Слайд 12 Depression and Antidepressants
Key facts:

Depression is a common mental

Depression and Antidepressants Key facts:Depression is a common mental disorder. Globally,

disorder. Globally, more than 350 million people of all

ages suffer from depression
Depression is the leading cause of disability worldwide, and is a major contributor to the global burden of disease
More women are affected by depression than men
At its worst, depression can lead to suicide
There are effective treatments for depression

Слайд 13 Drugs used for the treatment of depression:
Selective

Drugs used for the treatment of depression: Selective serotonin reuptake inhibitors

serotonin reuptake inhibitors (SSRIs)
Serotonin/norepinephrine reuptake inhibitors (SNRIs)
Atypical antidepressants
Tricyclic antidepressants

(TCAs)
Monoamine oxidase inhibitors (MAOIs)
St. John’s wort ( Hypericum perforatum)

Слайд 14 Selective serotonin reuptake inhibitors, SSRIs
Citalopram (Celexa) 
Escitalopram (Lexapro) 
Fluoxetine

Selective serotonin reuptake inhibitors, SSRIs Citalopram (Celexa) Escitalopram (Lexapro) Fluoxetine (Prozac) Paroxetine (Paxil) Sertraline (Zoloft) Vilazodone (Viibryd)Vortioxetine (Brintellix)

(Prozac) 
Paroxetine (Paxil) 
Sertraline (Zoloft) 
Vilazodone (Viibryd)
Vortioxetine (Brintellix)


Слайд 15 Serotonin/norepinephrine reuptake inhibitors, SNRIs
Desvenlafaxine (Pristiq) 
Duloxetine (Cymbalta)
Venlafaxine (Effexor, Effexor

Serotonin/norepinephrine reuptake inhibitors, SNRIs Desvenlafaxine (Pristiq) Duloxetine (Cymbalta)Venlafaxine (Effexor, Effexor XR)Levomilnacipran (Fetzima)

XR)
Levomilnacipran (Fetzima)


Слайд 16 Other Antidepressants
Bupropion (Wellbutrin)
Mirtazapine (Remeron, Remeron SolTab)
Trazodone (Desyrel,

Other Antidepressants Bupropion (Wellbutrin)Mirtazapine (Remeron, Remeron SolTab)Trazodone (Desyrel, Oleptro)

Oleptro)


Слайд 17 Tricyclic antidepressants, TCAs
Amitriptyline (Elavil) 
Desipramine (Norpramin) 
Imipramine (Tofranil) 
Clomipramine (Anafranil) 
Nortriptyline (Pamelor) 
Protriptyline

Tricyclic antidepressants, TCAs Amitriptyline (Elavil) Desipramine (Norpramin) Imipramine (Tofranil) Clomipramine (Anafranil) Nortriptyline (Pamelor) Protriptyline (Vivactil)Doxepin (Sinequan, Silenor)Trimipramine (Surmontil) Amoxapine 

(Vivactil)
Doxepin (Sinequan, Silenor)
Trimipramine (Surmontil) 
Amoxapine
 


Слайд 18 Monoamine oxidase inhibitors,MAO Is
Selegiline transdermal patch (Emsam)
Tranylcypromine (Parnate) 
Phenelzine

Monoamine oxidase inhibitors,MAO IsSelegiline transdermal patch (Emsam)Tranylcypromine (Parnate) Phenelzine (Nardil) Isocarboxazid (Marplan)

(Nardil) 
Isocarboxazid (Marplan)


Слайд 19 Herbals
Hypericum perforatum (St John's Wort)


HerbalsHypericum perforatum (St John's Wort)

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